(CNN) - A top infectious disease expert says rising COVID-19 cases and hospitalizations may be the start of another surge in U.S.
More than seven months into this pandemic, the U.S. is sliding backwards.
"This is going to be a very tough winter," Dr. Peter Hotez, dean of the National School of Medicine at Baylor College of Medicine said. "We may see a rise new cases that exceed what we saw back in March and April."
Thirty-three states seeing new cases rise over the past week.
Nearly half of those also posting their highest seven-day averages for new cases.
"Now is the time act," Dr. Rochelle Walensky said. "Now is the time to do something about it."
COVID-related hospitalizations at record highs in five states.
"Our enemy isn't knowing what to do any longer, our enemy is helping people understand why it's in their best interest and our best interest," said Andy Slavitt, former acting administrator of the Centers for Medicare and Medicaid Services.
In New York, hefty fines and tickets as the city tries to contain clusters by enforcing masks, limiting gatherings and closing non-essential businesses
"We're now in day four of the pause in those areas and we are seeing some results," Mayor Bill De Blasio of New York City said.
Dr. Deboarh Birx in New Hampshire warning now is not the time to let your guard down
"This virus can spread among families and friends if you take your mask off and you are primarily indoors," Birx said.
A message plenty of Americans are still ignoring, starting at the top.
This Sunday concert in Nashville, now under investigation
"It's officially a protest, ok, so it's legal," Sean Feucht said.
For gathering without a permit and exceeding the city's current max of 25 people. The mask mandate, also largely ignored
"If you were at that event, you should lay low and stay home," Dr. David Aronoff of Vanderbilt University Medical Center said.
Johnson and Johnson pausing Phase III of its vaccine trial because of an unexpected illness in one of the volunteers.
"To me, it is reassuring that companies are pausing when they need to," said Dr. Ashish Jha, dean of Brown University School of Public Health.
Astra-Zeneca's U.S. trials remain on hold, pending an FDA investigation.
A set-back for soccer star Cristiano Ronaldo -- now in isolation after testing positive.
Meantime in Dallas, a big moment for major league baseball. More than 11,000 were allowed in for game one of the NLCS.
"It's just great to have baseball fans in the stands again," Freddie Freeman, Braves First Baseman said.
Officials across the country are warning of similar coronavirus patterns.
Last week, White House coronavirus task force coordinator Dr. Deborah Birx warned that the northeast was seeing "early suggestions" of alarming trends.