The westbound lanes on I-10 are now open at Tangerine road in Marana, according to the Arizona Department of Transportation.
The closure was due to crashes at mileposts 230 and 236.
Officials with the Arizona Department of Public Safety say the crash at milepost 230 was fatal.
Details are limited at this time.
Officials say motorists should expect delays between Cotaro Farms and Tangerine roads as backed up traffic clears.